盐酸纳呋拉啡
盐酸纳呋拉啡
Nalfurafine Hydrochloride
盐酸纳呋拉啡
Nalfurafine Hydrochloride
-
产品编号： CNR255600
-
CAS号： 152658-17-8
-
分子式：C28H33ClN2O5
-
分子量：513.03
英文别名：
(2E)-N-[(5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-2-propenamide Hydrochloride; (-)-17-(Cyclopropylmethyl)-3,14β-
dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan Hydrochloride; Rem
SMILES：
NC(=O)C1=CN(C=CC1[2H])[C@H]2[C@H](O)[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OC[C@@H]3[C@@H](O)[C@@H](OP(O)(O)=O)[C@@H](O3)N4C5C(=C(N)N=CN=5)N=C4)O2
储存条件：
Controlled Substance, -20˚C Freezer
参考文献：
Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004), Mori, T., et al.: Life Sci., 75, 2433 (2004), Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006), Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010),
Nalfurafine hydrochloride was launched on March of 2009 in Japan as the first in class non-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rat
搜索质检报告(COA)
搜索MSDS
