L-744832
Ras法呢基转移酶抑制剂；(2S)-[(2S)-[(2R)-氨基-3-巯基]-丙基氨基-(3S)-甲基]戊基氧-3-苯丙酰-蛋氨酸砜异丙酯盐酸盐
L-744832
Ras法呢基转移酶抑制剂；(2S)-[(2S)-[(2R)-氨基-3-巯基]-丙基氨基-(3S)-甲基]戊基氧-3-苯丙酰-蛋氨酸砜异丙酯盐酸盐
L-744832
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产品编号： CLR744832
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CAS号： 1177806-11-9
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分子式：C26H47Cl2N3O6S2
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分子量：632.7
英文别名：
(2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride
熔点：
165-168°C
可溶性：
Acetonitrile, Methanol
性状：
White Solid
储存条件：
-20°C Freezer
参考文献：
Barrington, R.E., et al.: Mol. Cell. Biol., 18, 85 (1998, Sepp-Lorenzo, L. and Rosen, N.: J. Biol. Chem., 273, 20243 (1998), Moasser, M.M., et al.: Proc. Natl. Acad. Sci. USA, 95, 1369 (1998), Law, B.K., et al.: J. Biol. Chem., 275, 10796 (2000),
Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.
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