LY-2228820
p38MAPK抑制剂
LY-2228820
p38MAPK抑制剂
LY-2228820
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产品编号： CLR486500
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CAS号： 862507-23-1
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分子式：C26H37FN6O6S2
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分子量：612.74
英文别名：
5-[2-(1,1-Dimethylethyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate
SMILES：
O=C1CCC[C@@H]2[C@H]3CN4CCCC[C@H]4[C@H](CN12)C3
参考文献：
Zhao, R. et al.: Drug Metab. Disp., 37, 1251 (2009); Ishitsuka, K. et al.: Br. J. Haematol., 141, 598 (2008); Mader, M. et al.: Bioorg. Med. Chem. Lett., 18, 179 (2008);
LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events.
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