Lomeguatrib
MGMT抑制剂；罗米鲁曲
Lomeguatrib
MGMT抑制剂；罗米鲁曲
Lomeguatrib
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产品编号： CLR469700
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CAS号： 192441-08-0
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分子式：C10H8BrN5Os
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分子量：326.17
英文别名：
6-[(4-Bromo-2-thienyl)methoxy]-9H-purin-2-amine
SMILES：
C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])(=O)C(C1=CC=CC=C1)(C1=CC=CC=C1)CCN1CCC(C2=CC=C(Cl)C=C2)(O)CC1.Cl
参考文献：
Reinhard, et al.: J. Med. Chem., 44, 4050 (2001), Barvaux, et al.: Mol. Cancer Ther., 3, 1215 (2004), Clemons, et al., Br. J. Cancer, 93, 1152 (2005),
Lomeguatrib is an inhibitor of O6-methylguanine-DNA methyltransferase (MGMT). Lomeguatrib attenuates MGMT activity in vitro and in vivo. Lomeguatrib enhances the antitumor activity of temozolomide in both human melanoma and MCF-7 xenografts.
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