洛哌丁胺 N-氧化物
洛哌丁胺前体；洛哌丁胺 N-氧化物
Loperamide N-Oxide
洛哌丁胺前体；洛哌丁胺 N-氧化物
Loperamide N-Oxide
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产品编号： CLR469460
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CAS号： 106900-12-3
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分子式：C29H33ClN2O3
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分子量：493.04
英文别名：
trans-
SMILES：
O=C(OCCN1CCN(CC1)S(=O)(=O)C2C=C(C(OCC)=CC=2)C3=NC4=C(N(C)N=C4CCC)C(=O)N3)OCCN5CCN(CC5)S(=O)(=O)C6C=C(C(OCC)=CC=6)C7=NC8=C(N(C)N=C8CCC)C(=O)N7
参考文献：
Lavrijsen, K., et al.: Drug Metab. Dispos., 23, 354
Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
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