Lonafarnib
氯雷他定-d4 N-氧化物；氯雷他定 N-氧化物-d4
Lonafarnib
氯雷他定-d4 N-氧化物；氯雷他定 N-氧化物-d4
Lonafarnib
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产品编号： CLR469445
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CAS号： 193275-84-2
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分子式：C22H19D4ClN2O2
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分子量：402.91
英文别名：
4-(8-Chloro-5,6-dihydro-1-oxido-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic-d4 Acid Ethyl Ester; Sch 38554-d4
SMILES：
NC(N1CCC(CC(N2CCC([C@H]3C4N=CC(=CC=4CCC4C=C(C=C(Br)C3=4)Cl)Br)CC2)=O)CC1)=O
参考文献：
Liu, M. et al.: Cancer Res., 58, 4947 (1998); Basso, A. et al.: J. Biol. Chem., 280, 31101 (2005); Sun, S. et al.: J. Biol. Chem., 282, 18800 (2007);
An orally bioavailable tricyclic inhibitor of farnesyl protein transferase. It inhibits Rheb farnesylation and mTOR signaling and enhances taxane and tamoxifen antitumor activity. Studies show that it induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells
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