来氟米特-d4
来氟米特-d4
Leflunomide-d4
来氟米特-d4
Leflunomide-d4
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产品编号： CLR322752
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CAS号： 1189987-23-2
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分子式：C12H5D4F3N2O2
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分子量：274.23
英文别名：
5-Methylisoxazole-4-[4-trifluoromethylcarboxanilide]-d4; Leflunomida-d4;
熔点：
161-163°C
可溶性：
Dichloromethane, Ether, Ethyl Acetate, Methanol
性状：
Off White Crystalline Solid
SMILES：
C1(C)=C(C(OC)=O)[C@@H](C2C=CC=C([N+]([O-])=O)C=2)C(C(=O)OC(C)(C)CN(C([2H])([2H])[2H])CCC(C2C=CC=CC=2)C2C=CC=CC=2)=C(C)N1.Cl
储存条件：
-20°C Freezer
参考文献：
Vrenken, T., et al.: J. Hepatol., 49, 799 (2008),
An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases.
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