来氟米特
来氟米特
Leflunomide
来氟米特
Leflunomide
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产品编号： CLR322750
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CAS号： 75706-12-6
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分子式：C12H9F3N2O2
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分子量：270.21
英文别名：
5-Methylisoxazole-4-[4-trifluoromethylcarboxanilide]; Leflunomida;
熔点：
153-156°C
可溶性：
Dichloromethane, Ether, Ethyl Acetate, Methanol
性状：
Off White Solid
SMILES：
Cl.COC(C1=C(C)NC(C)=C(C(OC(CN(CCC(C2=CC=CC=C2)C2=CC=CC=C2)C)(C)C)=O)[C@@H]1C1C=CC=C([N+](=O)[O-])C=1)=O
储存条件：
-20°C Freezer
参考文献：
Vrenken, T., et al.: J. Hepatol., 49, 799 (2008),
An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).
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