L-798106-d6
前列腺素类受体EP3-选择性拮抗剂内标物
L-798106-d6
前列腺素类受体EP3-选择性拮抗剂内标物
L-798106-d6
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产品编号： CLR011502
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相关CAS号：244101-02-8（未标记）
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分子式：C27H16D6BrNO4S
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分子量：542.47
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EINECES：208-276-6
英文别名：
CM-9-d6；GW-671021-d6；(2E)-N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide-d6
SMILES：
C1=CC=C(C=C1)C(C2=CC=CC=C2)C3NCCCC3
参考文献：
Kobayashi, K. et al.: Eur. J. Pharmacol., 660, 375 (2011); Su, X. et al.: Am. J. Physiol. Renal Physiol., 295, F984 (2008); Bassil, A.K. et al.: Br. J. Pharmacol. 154, 126 (2008); Jugus, M.J. et al.: Br. J. Pharmacol., 158, 372 (2009); Juteau, H. et al.:
Labelled analogue of L-798106, a potent and selective prostanoid receptor EP3-selective antagonists. L-798106 has been used in multiple studies to tease out EP3 agonist activity, both in vitro and in vivo. L-798106 successfully blocks the actions of sulprostone, an EP3-selective agonist. L-798106 was useful in showing that the vascular contraction effect of PGE2 is due to its prostanoid EP3 agonist activity.
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