L-798106
前列腺素类受体EP3-选择性拮抗剂；(2E)-N-[(5-溴-2-甲氧苯基)磺酰基]-3-[2-(2-萘甲基)苯基]-2-丙酰胺
L-798106
前列腺素类受体EP3-选择性拮抗剂；(2E)-N-[(5-溴-2-甲氧苯基)磺酰基]-3-[2-(2-萘甲基)苯基]-2-丙酰胺
L-798106
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产品编号： CLR011500
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CAS号： 244101-02-8
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分子式：C27H22BrNO4S
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分子量：536.44
英文别名：
CM 9；GW-671021；(2E)-N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
参考文献：
Kobayashi, K. et al.: Eur. J. Pharmacol., 660, 375 (2011); Su, X. et al.: Am. J. Physiol. Renal Physiol., 295, F984 (2008); Bassil, A.K. et al.: Br. J. Pharmacol. 154, 126 (2008); Jugus, M.J. et al.: Br. J. Pharmacol., 158, 372 (2009); Juteau, H. et al.:
L-798106 is a potent and selective prostanoid receptor EP3-selective antagonists. L-798106 has been used in multiple studies to tease out EP3 agonist activity, both in vitro and in vivo. L-798106 successfully blocks the actions of sulprostone, an EP3-selective agonist. L-798106 was useful in showing that the vascular contraction effect of PGE2 is due to its prostanoid EP3 agonist activity.
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