KU-0058948
ERK8激动剂；PARP抑制剂
KU-0058948
ERK8激动剂；PARP抑制剂
KU-0058948
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产品编号： CKR660400
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CAS号： 763111-49-5
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分子式：C21H21FN4O2
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分子量：380.42
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EINECES：208-382-2
英文别名：
4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone; KU 0058948; KU0058948; 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine;
熔点：
150-152°C
可溶性：
DMSO, Methanol
性状：
Pale Yellow Solid
SMILES：
O1C=CC=C1CNC1N=CN=C2C=1N=CN2
储存条件：
Refrigerator
参考文献：
Klevernic, I.V. et al.: FEBS Lett., 583, 680 (2009); Gaymes, T.J. et al.: Haematologica, 94, 638 (2009);
KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro
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