Kifunensine
Kifunensine
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Kifunensine
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Kifunensine
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产品编号: CKR450000
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CAS号: 109944-15-2
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分子式:C8H12N2O6
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分子量:232.19
英文别名:
(+)-Kifunensine
熔点:
>280°C (dec.)
可溶性:
DMSO, Hot Water
性状:
White Solid
储存条件:
-20°C Freezer
参考文献:
Iwami, M., et al.: J. Antibiotic., 40, 612 (1987); Elbein, A.D., et al.: J. Biol. Chem., 265, 15599 (1990); Elbein, A.D., et al.: Archives of Biochem & Biophys., 288, 1, 177 (1991); Kayakiri, H., et al.: Chem. Pharm. Bull., 39(6), 1378 (1991)
Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis.
When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin.
Physicochemical characteristics: Kifunensine is soluble in hot water. Solutions should be made immediately prior to use. The compound should be dessicated and stored at -20 deg C.
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