Kartogenin
4’-苯基酞酰替苯胺酸
Kartogenin
4’-苯基酞酰替苯胺酸
Kartogenin
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产品编号： CKR139800
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CAS号： 4727-31-5
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分子式：C20H15NO3
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分子量：317.34
英文别名：
KGN
SMILES：
CSC1=CC(OC)=C(C=C1)C(=O)N2CCC(CC3=CC=CC=C3)CC2
参考文献：
Ruschig, H., et al.: Arzneim.-Forsch. Drug Res., 23, 1745 (1973), Hartmann, R., et al.: J. Med. Chem., 35, 2210 (1992), Kishida., et al.: Biochemistry, 45, 783 (2006), Chem. and Eng. News 90, 34 (2012)
Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.
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