JW-55
TNKS1/2PARP域抑制剂；N-[4-[[[[四氢-4-(4-甲氧苯基)-2H-吡喃-4-基]甲基]氨基]甲酰]苯基]-2-呋喃甲酰胺
JW-55
TNKS1/2PARP域抑制剂；N-[4-[[[[四氢-4-(4-甲氧苯基)-2H-吡喃-4-基]甲基]氨基]甲酰]苯基]-2-呋喃甲酰胺
JW-55
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产品编号： CJR211325
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CAS号： 664993-53-7
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分子式：C25H26N2O5
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分子量：434.48
英文别名：
N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
SMILES：
CC/C=C/CC1C(=O)C[C@H](OC([C@@H]2[C@@H](/C=C(/C(OC)=O)\C)C2(C)C)=O)C=1C
参考文献：
Waaler, et al., et al.: Cancer Res., 72, 2822 (2012);
JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.
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