J-147
2,2,2-三氟乙酸 1-(2,4-二甲基苯基)-2-[(3-甲氧苯基)亚甲基]酰肼
J-147
2,2,2-三氟乙酸 1-(2,4-二甲基苯基)-2-[(3-甲氧苯基)亚甲基]酰肼
J-147
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产品编号： CJR210300
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CAS号： 1146963-51-0
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分子式：C18H17F3N2O2
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分子量：350.33
英文别名：
2,2,2-Trifluoroacetic Acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
SMILES：
Cl.CN(CCOC1=CC=C(CNC(C2=CC=C(OC)C(OC)=C2)=O)C=C1)C
参考文献：
Chen, J., et al.: J. Neurosci., 25, 2366 (2005), Maher, P., et al.: Brain Res., 1173, 117 (2007), Liu, Y., et al.: J. Neurochem., 105, 1336 (2008), Herrup, K., et al.: J. Neurosci., 30, 16755 (2010)
J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.
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