exo-IWR-1
rel-4-[(3aR,4R,7S,7aS)-1,3,3a,4,7,7a-六氢-1,3-二酮代-4,7-甲桥-2H-异吲哚-2-基]-N-8-喹啉苯甲酰胺
exo-IWR-1
rel-4-[(3aR,4R,7S,7aS)-1,3,3a,4,7,7a-六氢-1,3-二酮代-4,7-甲桥-2H-异吲哚-2-基]-N-8-喹啉苯甲酰胺
exo-IWR-1
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产品编号： CIR941805
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CAS号： 1127442-87-8
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分子式：C25H19N3O3
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分子量：409.44
英文别名：
rel-4-[(3aR,4R,7S,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
参考文献：
Lepourcelet, M., et al.: Cancer Cell, 5, 91 (2004), Barker, N., et al.: Nat. Rev. Drug Disc., 5, 997 (2006), Clevers, H., et al.: Cell, 127, 469 (2006), Jin, G., et al.: Bioorg. Med. Chem. Lett., 19, 606 (2009),
exo-IWR-1 is the enantiomer of IWR-1 (I941800). exo-IWR-1 is an SAR anticancer Wnt response inhibitor. Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
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