盐酸法舒地尔
盐酸法舒地尔；1-(5-异喹啉磺酰基)-1H-六氢-1,4-二氮杂卓盐酸盐
Fasudil Dihydrochloride
盐酸法舒地尔；1-(5-异喹啉磺酰基)-1H-六氢-1,4-二氮杂卓盐酸盐
Fasudil Dihydrochloride
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产品编号： CIR882200
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CAS号： 103745-39-7
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分子式：C14H19Cl2N3O2S
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分子量：364.28
英文别名：
HA1077, Fasudil；1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride
熔点：
238-242°C
可溶性：
Methanol, Water
性状：
White to Off-White Solid
SMILES：
C(C1=CSC(C(O)=O)=N1)(C)C
储存条件：
-20°C Freezer
参考文献：
Hidaka, H., et al.: Acta Nurochir. (Wien), 90 (1988) Sward., K., el a.: J. Physiol., 522, 33 (2000),
A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
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