异烟肼
异烟肼
Isoniazid
异烟肼
Isoniazid
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产品编号： CIR821450
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CAS号： 54-85-3
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分子式：C6H7N3O
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分子量：137.14
英文别名：
4-Pyridinecarboxylic Acid Hydrazide; Isonicotinic Acid Hydrazide; 4-(Hydrazinocarbonyl)pyridine; 4-Pyridinecarbonylhydrazine; 4-Pyridinecarboxylic Hydrazide; 4-Pyridylcarbonylhydrazide; 5015 R.P.; Armazid; Armazide; Atcotibine;
Isonizide; Isotebezid; Isoz
熔点：
167-169°C
可溶性：
DMSO, Methanol
性状：
White Solid
SMILES：
O.OC[C@H]1O[C@H](OC[C@H]2OC(O)(CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
储存条件：
Refrigerator
参考文献：
Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)
Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).
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