异甘草素
异甘草素；异甘草黄素
Isoliquiritigenin
异甘草素；异甘草黄素
Isoliquiritigenin
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产品编号： CIR820850
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CAS号： 961-29-5
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分子式：C15H12O4
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分子量：256.25
英文别名：
(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; ISL; 2',4,4'-Trihydroxychalcone; 2',4,4'-Trihydroxychalcone; GU 17;
SMILES：
COC1C(N2CCNCC2C)=C(F)C=C2C=1N(C1CC1)C=C(C2=O)C(=O)O
参考文献：
Agrawal, R., et al.: Food Chem. Toxicol., 36, 975 (1998), Baba, M., et al.: Biol. Pharm. Bull., 25, 247 (2002), Chowdhury, S., et al.: Anticancer Res., 25, 2055 (2005),
Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. ISL induces quinone reductase-1, a phase II enzyme that deactivates radicals and electrophiles, with a concentration required to double activity (CD) value of 1.8 μM in murine hepatoma cells.
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