艾沙康唑
艾沙康唑
Isavuconazole
艾沙康唑
Isavuconazole
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产品编号： CIR777830
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CAS号： 241479-67-4
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分子式：C22H17F2N5Os
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分子量：437.47
英文别名：
4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile; 2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-
difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;
SMILES：
CCCCC1N(CC2=CC=C(C=C2)C3C(=CC=CC=3)C4=NN(N=N4)[C@@H]5[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C(C(=O)OC)O5)C(=O)C6(CCCC6)N=1
参考文献：
Ohwada, J., et al.: Bioorg. Med. Chem. Lett., 13, 191 (2003), Guinea, J., et al.: Antimicrob. Agents Chemother., 52, 1396 (2008)
Isavuconazole is a new triazole currently undergoing phase III clinical trials. This compound has shown in vitro activity against a large number of clinical important yeasts and molds including Aspergillus spp., Fusarium spp., Scedosporium spp., Candida spp., the Zygomycetes and Cryptococcus spp.
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