IQ-1
2-[2-(4-乙酰苯基)偶氮基]-2-(3,4-二氢-3,3-二甲基-1(2H)-异喹啉亚基)-乙酰胺
IQ-1
2-[2-(4-乙酰苯基)偶氮基]-2-(3,4-二氢-3,3-二甲基-1(2H)-异喹啉亚基)-乙酰胺
IQ-1
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产品编号： CIR748570
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CAS号： 331001-62-8
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分子式：C21H22N4O2
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分子量：362.42
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EINECES：248-887-5
英文别名：
2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide
SMILES：
C(NC1=C(I)C(C(=O)NCCO)=C(I)C(C(O)=O)=C1I)(=O)C
参考文献：
Kanai., et al.: The Pharmacogenomics J., 4, 336 (2004), Miki., et al.: Stem Cells, 23, 1549 (2005), T. Miyabayashi, et al.: Proc. Natl. Acad. Sci., 104, 5668 (2007), Luo., et al.: Ann. Neurol., 65, 520 (2009),
IQ 1 disrupts Wnt signaling. IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription.
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