5-碘尿嘧啶
5-碘尿嘧啶；5-碘-2,4-二羟基嘧啶；5-碘-2,4-吡啶二酮
5-Iodouracil
5-碘尿嘧啶；5-碘-2,4-二羟基嘧啶；5-碘-2,4-吡啶二酮
5-Iodouracil
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产品编号： CIR728900
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CAS号： 696-07-1
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分子式：C4H3In2O2
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分子量：237.98
英文别名：
5-Iodo-2,4(1H,3H)-pyrimidinedione; 5-Iodo-2,4-dihydroxypyrimidine; 5-Iodo-2,4-pyrimidinedione; 5-Iodopyrimidine-2,4-diol; 5-Iodouracil; NSC 57848;
熔点：
266-270°C
可溶性：
DMSO, Methanol
性状：
Off-White Solid
SMILES：
ONC(CCCCCCC(NC1C=CC(I)=CC=1)=O)=O
储存条件：
Refrigerator
参考文献：
Meisenheimer, K. et al.: Meth. Enzymol., 318, 88 (2000); Klecker, R.W. Jr. et al.: Cancer Chemother. Pharmacol., 48, 407 (2001); Turner, D.P. et al.: Cancer Res., 66, 7686 (2006);
5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.
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