HZ-52
5-脂氧合酶抑制剂
HZ-52
5-脂氧合酶抑制剂
HZ-52
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产品编号： CHR999750
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分子式：C24H26ClN3O2S
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分子量：456
英文别名：
2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]octanoic Acid
SMILES：
OC(CCC(C1CCC2C3CC(O)C4CC(CCC4(C)C3CCC12C)O)C)=O
参考文献：
Greiner, C. et al.: Br. J. Pharmacol., 164, 781 (2011); Koeberle, A. et al.: J. Med. Chem., 51, 8068 (2008);
A potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. It also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally.
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