Hymenialdisine Analogue #1
Hymenialdisine类似物#1
Hymenialdisine Analogue #1
Hymenialdisine类似物#1
Hymenialdisine Analogue #1
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产品编号： CHR998025
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CAS号： 693222-51-4
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分子式：C15H13N5O2
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分子量：295.3
英文别名：
5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidene)-3,4,5,10-tetrahydro-2H-azepino[3,4-b]indol-1-one
可溶性：
Butanol, DMSO,
性状：
Light Yellow Solid
SMILES：
OC1C2C=CC=C(O)C=2OC(=O)C=1C(C1C=CC=CC=1)CC(=O)C
储存条件：
-20˚C Freezer
参考文献：
Sharma, V., and Tepe, J.J.: Bioorg. & Medicinal Chem. Letters, 14, 4319 (2004), Sharma, V., et al.: J. Med. Chem., 47, 3700 (2004)
The indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. This compound exhibits very potent inhibition of Chk2 activity in the low nanomolar range (IC50=8nM). Exhibits an increased selectivity for the checkpoint kinases over natural Hymenialdisine.
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