6-羟基左旋多巴
6-羟基左旋多巴
左旋多巴杂质A;6-羟基左旋多巴;2,4,5-三羟基-L-苯丙氨酸
6-Hydroxy-L-DOPA
左旋多巴杂质A;6-羟基左旋多巴;2,4,5-三羟基-L-苯丙氨酸
6-Hydroxy-L-DOPA
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产品编号: CHR941725
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CAS号: 27244-64-0
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分子式:C9H11NO5
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分子量:213.19
英文别名:
TOPA
参考文献:
Jaim-Etcheverry, G. et al.: Brain Res., 100, 699 (1975); Kostrzewa, R.M. et al.: Amino Acids, 14, 175 (1998); Berthet, A. et al.: J. Neurosci., 29, 4829 (2009);
6-Hydroxy-L-DOPA is the 6-hydroxy derivative of the amino acid L-DOPA (D533751) with neurotoxic properties. Studies show that exogenously administered 6-Hydroxy-L-DOPA is biotransformed by amino acid decarboxylase to the highly potent and catecholamine-selective neurotoxin, 6-Hydroxydopamine. The treatment of 6-Hydroxy-L-DOPA in rats resulted in the stimulation of acetylcholinesterase.
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