N-羟基-N’-(4-丁基-2-甲基苯基)甲脒
N-羟基-N’-(4-丁基-2-甲基苯基)甲脒
N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine
N-羟基-N’-(4-丁基-2-甲基苯基)甲脒
N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine
-
产品编号： CHR831225
-
CAS号： 339068-25-6
-
分子式：C12H18N2O
-
分子量：206.28
英文别名：
HET-0016
可溶性：
DMSO
性状：
Light Pink Solid
参考文献：
Miyata, N., et al.: Br. J. Pharmacol., 133, 325 (2001), Amaral, S.L., et al.: Am. J. Physiol. Heart Circ. Physiol., 284, H1528 (2003), Mulligan, S.J. and MacVicar, B.A.: Nature, 431, 195 (2004), Poloyac, S.M., et al.: J. Ceteb. Blood Flow Metab., March 29
HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A (IC50=8.9nM (human), 35nM (rat renal microsome). IC50 cyclooxygenase=2.3uM. IC50 for other CYP’s: CYP2C9-3.3uM, CYP2D6=83.9 uM, CYP3A4=71uM. It inhibits cerebrovascular constriction induced by Ca2+ or archidonate and inhibits angiogenesis and endothelial cell sprouting in various models. Displays protective effect on brain damage after temporary focal ischemia (at 10mg/Kg).
搜索质检报告(COA)
搜索MSDS
