HA-150
autotaxin抑制剂；B-[3-[[4-[[3-[(4-氟苯基)甲基]-2,4-二氧戊环-5-噻唑烷亚基]甲基]苯氧基]甲基]苯基]硼酸
HA-150
autotaxin抑制剂；B-[3-[[4-[[3-[(4-氟苯基)甲基]-2,4-二氧戊环-5-噻唑烷亚基]甲基]苯氧基]甲基]苯基]硼酸
HA-150
-
产品编号： CHR011600
-
CAS号： 1229652-21-4
-
分子式：C24H19BFNO5S
-
分子量：463.29
英文别名：
B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]boronic Acid
SMILES：
CCOC1N=CC(CC2C(=O)N=C(SCC3C=CC(F)=CC=3)N(C3C=CC(C(OCC)=O)=CC=3)C=2)=CN=1
参考文献：
Albers, H.M.H.G. et al.: Proc. Natl. Acad Sci. USA, 107, 7257 (2010); Albers, H.M.H.G. et al.: J. Med. Chem., 53, 4958 (2010);
HA 150 is a selective boronic acid-based inhibitor of autotaxin. Studies show that adminstration of HA 150 in mice results in rapid decrease of the lipid mediator lysophosphatidic acid (LPA) in the circulation. These findings suggest that HA 150 may provide useful therapeutic strategy in treating disorders associated with vascular development, inflammation, fibrotic disease, and tumor progression.
搜索质检报告(COA)
搜索MSDS
