H-1152 盐酸盐
ROCK抑制剂；H-1152 盐酸盐；5-[[(2S)-六氢-2-甲基-1H-1,4-二氮杂卓-1-基]磺酰]-4-甲基异喹啉盐酸盐
H-1152 Dihydrochloride
ROCK抑制剂；H-1152 盐酸盐；5-[[(2S)-六氢-2-甲基-1H-1,4-二氮杂卓-1-基]磺酰]-4-甲基异喹啉盐酸盐
H-1152 Dihydrochloride
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产品编号： CHR011520
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CAS号： 871543-07-6
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分子式：C16H23Cl2N3O2S
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分子量：392.34
英文别名：
5-[[(2S)-Hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methylisoquinoline Dihydrochloride
熔点：
182-184°C
可溶性：
Methanol, Water
性状：
White to Off-White Solid
SMILES：
COC1C=CC(C2SC3C=CC(=CC=3N=2)F)=CC=1OC
储存条件：
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
参考文献：
Ikenoya, M., et al.: J. Neurochem., 81, 9 (2002), Sasaki, Y., et al.: Pharmacol. Ther., 93, 225 (2002)
ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.
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