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GW-6471
PPARα拮抗剂
GW-6471
  • 产品编号: CGR931200

  • CAS号: 880635-03-0

  • 分子式:C35H36F3N3O4

  • 分子量:619.67

英文别名:
N-[(2S)-2-[[(1Z)-1-Methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]propanamide
参考文献:
Xu, H.E. et al.: Nature, 415, 813 (2002); Muller, M.Q. et al.: J. Med. Chem., 52, 2875 (2009);
GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.
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