3-Fluoro-GSK2606414
GSK-PERK抑制剂；1-[5-(4-氨基-7-甲基-7H-吡咯并[2,3-d]嘧啶-5-基)-2,3-二氢-1H-吲哚-1-基]-2-[3-氟-5-(三氟甲基)苯基]乙酮
3-Fluoro-GSK2606414
GSK-PERK抑制剂；1-[5-(4-氨基-7-甲基-7H-吡咯并[2,3-d]嘧啶-5-基)-2,3-二氢-1H-吲哚-1-基]-2-[3-氟-5-(三氟甲基)苯基]乙酮
3-Fluoro-GSK2606414
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产品编号： CGR797800
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CAS号： 1337531-89-1
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分子式：C24H19F4N5O
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分子量：469.43
英文别名：
GSK-PERK Inhibitor；1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone
熔点：
237-240°C (dec.)
可溶性：
DMSO
性状：
Pale Yellow Solid
SMILES：
CN(CC(N1CCC2=CC(=C(C=C12)NC1=NC2NC=CC=2C(NC2C=CC=C(F)C=2C(NC)=O)=N1)OC)=O)C
储存条件：
Refrigerator
参考文献：
Baltzis, D. et al.: J. Biol. Chem., 282, 31675 (2007); Axten, J. M.et al,: J. Med. Chem. 55(16) 7193 (2012).
GSK PERK Inhibitor is an inhibitors of PERK, an important transmembrane protein of endoplasmic reticulum (ER). GSK PERK Inhibitor can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response p
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