GSK-4112
REV-ERBα相关物质
GSK-4112
REV-ERBα相关物质
GSK-4112
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产品编号： CGR797700
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CAS号： 1216744-19-2
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分子式：C18H21ClN2O4S
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分子量：396.89
英文别名：
N-[(4-Chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]glycine 1,1-Dimethylethyl Ester
SMILES：
CCCCCCN1C(=O)C(C(NC2=CC=C(C(OCCC)=O)C=C2)=O)=C(O)C2=CC=CC=C12
参考文献：
Kojetin, D. et al.: ACS Chem. Biol., 6, 131 (2011); Grant, D. et al.: ACS Chem. Biol., 5, 925 (2010);
GSK 4112 is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes inv
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