盐酸芬戈莫德
盐酸芬戈莫德
Fingolimod Hydrochloride
盐酸芬戈莫德
Fingolimod Hydrochloride
-
产品编号： CFR805000
-
CAS号： 162359-56-0
-
分子式：C19H34ClNO2
-
分子量：343.93
英文别名：
FTY720 Hydrochloride
熔点：
102-107°C
可溶性：
DMSO, Ethanol, Methanol
性状：
White Solid
SMILES：
OCC1(OC([2H])([2H])[C@@]([2H])(O)[C@@]([2H])(O)[C@@H]1O)O
储存条件：
-20°C Freezer
参考文献：
Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
搜索质检报告(COA)
搜索MSDS
