5-氟乳清酸一水合物
5-氟乳清酸一水合物
5-Fluoroorotic Acid Monohydrate
5-氟乳清酸一水合物
5-Fluoroorotic Acid Monohydrate
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产品编号： CFR595000
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CAS号： 703-95-7
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分子式：C5H5FN2O5
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分子量：192.1
英文别名：
5-FOA
熔点：
>260°C (dec.)
可溶性：
50mg in 1ml (1:1 Ammonium Hydroxide:Water) with Gentle Heating
性状：
White to Off-White Solid
SMILES：
FC1C=CC(S(N)(=O)=O)=CC=1[N+]([O-])=O
储存条件：
-20°C Freezer
参考文献：
Winston, F., et al.: Genetics, 107, 179 (1984); Boeke, J.D., et al.: Methods Enzymol., 154, 164 (1987); Rathod, P.K., et al.: Antimicrob. Agents Chemother., 33, 1090 (1989); Rathod, P.K., et al.: Antimicrob. Agents Chemother., 36, 704 (1992); Gomez, Z.M .
5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
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