1-[[3-氟-4-[5-[(2-氟苯基)甲基]-2-苯并噻唑基]苯基]甲基]-3-吖丁啶羧酸
鞘氨醇-1-磷酸酯受体1(S1P1)激动剂；1-[[3-氟-4-[5-[(2-氟苯基)甲基]-2-苯并噻唑基]苯基]甲基]-3-吖丁啶羧酸
1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic Acid
鞘氨醇-1-磷酸酯受体1(S1P1)激动剂；1-[[3-氟-4-[5-[(2-氟苯基)甲基]-2-苯并噻唑基]苯基]甲基]-3-吖丁啶羧酸
1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic Acid
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产品编号： CFR588420
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CAS号： 1257093-40-5
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分子式：C25H20F2N2O2S
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分子量：450.5
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EINECES：207-196-9
英文别名：
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SMILES：
FC1C=CC=CC=1CC(O)=O
参考文献：
Lanman, B.A. et al.: ACS Med. Chem. Lett., 2, 102 (2011);
1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic Acid is a potent Sphingosine-1-Phosphate Receptor 1 (S1P1) agonist with minimal activity at S1P3. It has been shown to attenuate DTH response to antigen challenge while significantly reducing blood lymphocyte counts.
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