Exenatide Acetate
醋酸艾塞那肽；胰高血糖素样肽-4
Exenatide Acetate
醋酸艾塞那肽；胰高血糖素样肽-4
Exenatide Acetate
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产品编号： CER957300
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CAS号： 141732-76-5
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分子式：C184H282N50O60S.C2H4O2
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分子量：4246.62
英文别名：
Exendin-4;
熔点：
210-217°C (dec.)
可溶性：
Water
性状：
White Solid
储存条件：
Refrigerator
参考文献：
Pugazhenthi, U. et al.: Diabetol., 53, 2357 (2010); Li, C. et al.: Bioche,. Biophys. Res. Comm., 400, 563 (2010); Lupi, R. et al.: Diab. Obes. Metab., 10, 515 (2008); Kim, T.H. et al.: Bioconj. Chem., 22, 625 (2011);
A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.
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