埃博霉素B
埃博霉素B；(-)-埃博霉素B(合成)
Epothilone B
埃博霉素B；(-)-埃博霉素B(合成)
Epothilone B
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产品编号： CER588990
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CAS号： 152044-54-7
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分子式：C27H41NO6S
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分子量：507.68
英文别名：
(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;
(-)-Epothilone B; EPO 906; EPO 906A; Epothilone B; Patupilone;
熔点：
95-97°C
可溶性：
Chloroform, Dichloromethane, DMSO, Ethanol, Methanol
性状：
White Powder
SMILES：
[K+].O=C(CC[C@@]1(CC[C@H]2[C@@H]3[C@H](C(OC)=O)CC4=CC(CC[C@]4(C)C43O[C@@H]4C[C@]12C)=O)O)[O-]
储存条件：
-20°C Freezer, Under Inert Atmosphere
参考文献：
Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995), Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (2001), Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
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