EB-47
PARP-1抑制剂；5'-脱氧-5'-[4-[2-[(2,3-二氢-1-酮代-1H-异吲哚-4-基)氨基]-2-酮代乙基]-1-哌嗪基]-5'-酮基腺苷盐酸盐
EB 47
PARP-1抑制剂；5'-脱氧-5'-[4-[2-[(2,3-二氢-1-酮代-1H-异吲哚-4-基)氨基]-2-酮代乙基]-1-哌嗪基]-5'-酮基腺苷盐酸盐
EB 47
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产品编号： CER320300
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CAS号： 366454-36-6
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分子式：C24H29Cl2N9O6
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分子量：610.45
英文别名：
5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine Dihydrochloride
SMILES：
N(C(C(OCC)=O)C(OCC)=O)C(N)=O
参考文献：
Jagtap, et al.: Bioorg. Med. Chem. Lett., 14, 81 (2004), Gaymes, et al.: Haematologica, 94, 638 (2009), Ferraris, et al.: J. Med. Chem. 53, 4561 (2010),
EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult.
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