阿洛司他丁
阿洛司他丁；阿洛司他汀
Aloxistatin
阿洛司他丁；阿洛司他汀
Aloxistatin
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产品编号： CER100500
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CAS号： 88321-09-9
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分子式：C17H30N2O5
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分子量：342.43
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EINECES：201-783-3
英文别名：
E-64d；(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic Acid Ethyl Ester; Aloxistatin; E 64c ethyl ester; E 64d; EP 453; EST; EST (pharmaceutical); Loxistatin; Loxistatin；NSC 694281
SMILES：
OC(C(O)C(OCC)=O)C(OCC)=O
参考文献：
Wilcox, D. et al.: Biochem. J., 285, 495 (1992); McGowan, E.B. et al.: Biochem. Biophys. Res. Comm., 158, 432 (1989); Tsubokawa, T. et al.: J. Neurosci. Res., 84, 832 (2006);
E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.
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