双氯非那胺
双氯非那胺
Diclofenamide
双氯非那胺
Diclofenamide
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产品编号： CDR436530
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CAS号： 120-97-8
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分子式：C6H6Cl2N2O4S2
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分子量：305.16
英文别名：
1,3-Disulfamoyl-4,5-dichlorobenzene; 1,3-Disulfamyl-4,5-dichlorobenzene; 3,4-Dichloro-5-sulfamylbenzenesulfonamide; 4,5-Dichloro-1,3-disulfamoylbenzene; 4,5-Dichloro-m-benzenedisulfonamide; Antidrasi; CB 8000; Daramide; Daranide; Dichlofenamide; Dichlorop
熔点：
237-240°C
可溶性：
Chloroform, Methanol
性状：
灰白色固体
SMILES：
OC[C@@H]1CO[C@](C2C=CC(Cl)=CC=2Cl)(CN2C=NC=N2)O1
储存条件：
冷藏
参考文献：
Brzozowski, Z. et al.: Eur. J. Med. Chem., 46, 3656 (2010); Tawil, R. et al.: Ann. Neurol., 47, 46 (2000); Casey, J. et al.: J. Med. Chem., 47, 2337 (2004);
Diclofenamide is a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP).
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