2,4-二苄基-5-酮代噻二唑烷-3-硫酮
GSK-3ß抑制剂III；2,4-二苄基-5-酮代噻二唑烷-3-硫酮
2,4-Dibenzyl-5-oxothiadiazolidine-3-thione
GSK-3ß抑制剂III；2,4-二苄基-5-酮代噻二唑烷-3-硫酮
2,4-Dibenzyl-5-oxothiadiazolidine-3-thione
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产品编号： CDR417960
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CAS号： 72966-20-2
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分子式：C16H14N2Os2
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分子量：314.43
英文别名：
2,4-Bis(phenylmethyl)-3-thioxo-1,2,4-thiadiazolidin-5-one; GSK-3ß Inhibitor III
熔点：
104-107°C
可溶性：
Chloroform, Dichloromethane, Ethyl Acetate
性状：
白色至灰白色固体
SMILES：
C1C=CC(CN2C=C(F)C(=O)N(CC3C=CC=CC=3)C2=O)=CC=1
储存条件：
-20°C
参考文献：
Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)
Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. An oxothiadiazolidine-3-thione analogue that acts as a non-ATP competitive inhibitor of GSK-3ß ( IC50 =10uM).
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