右雷佐生
右丙亚胺；右雷佐生
Dexrazoxane
右丙亚胺；右雷佐生
Dexrazoxane
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产品编号： CDR299050
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CAS号： 24584-09-6
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分子式：C11H16N4O4
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分子量：268.27
英文别名：
4,4’-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione; (S)-4,4’-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione; (+)-4,4’-Propylenedi-2,6-piperazinedione; (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane;
熔点：
188-193°C
可溶性：
DMSO (Slightly), Methanol (Slightly, Sonicated), Water
性状：
淡黄色固体
SMILES：
O=C1C=C[C@@]2([C@]3([C@@H](O)C[C@@]4([C@@]([C@@H](C[C@H]4[C@@H]3CCC2=C1)C)(O)C(=O)O)C)F)C
储存条件：
冷藏
参考文献：
Walker, D., et al.: Pediatr. Blood Cancer 60,616 (2013); Kang, M., et al.: J. Chemother., 24, 292 (2012); Lipshultz, S., et al.: New England J. Med., 35, 145 (2004)
Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
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