去[2’-(1H-四唑-5-基)]-2-氰基氯沙坦
氯沙坦钾衍生物；去[2’-(1H-四唑-5-基)]-2-氰基氯沙坦
Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan
氯沙坦钾衍生物；去[2’-(1H-四唑-5-基)]-2-氰基氯沙坦
Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan
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产品编号： CDR297670
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CAS号： 114772-55-3
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分子式：C22H22ClN3O
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分子量：379.88
英文别名：
4’-[[2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-[1,1’-biphenyl]-2-carbonitrile; 2-Butyl-4-chloro-1-[(2’-cyanobiphenyl-4-yl)methyl]-5-hydroxymethylimidazole; 4’-(2-Butyl-4-chloro-5-hydroxymethyl-1H-imidazol-1-yl)-1,1’-biphenyl-2-carbonitri
熔点：
158-159°C
可溶性：
DMSO, Ethyl Acetate
性状：
白色固体
SMILES：
CC1C=CC=C(C)C=1NC(C1CCCCN1)=O
储存条件：
冷藏
参考文献：
Madasu, S., et al.: Org. Process Res. Dev., 16, 2025 (2012); Pitt, B., et al.: The Lancet, 355, 1582 (2000); Wachtell, K., et al.: J. Am. Coll. Cardiol., 45, 712 (2005)
Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan is a derivative of Losartan Potassium (L470500), a an angiotensin II antagonist and is commonly used to significantly reduce risk of new onset atrial fibrillation and associated stroke in high-risk patients.
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