N-去甲基-4-羟基他莫昔芬
他莫昔芬代谢物；N-去甲基-4-羟基他莫昔芬 (1:1 E/Z混合物)
(E/Z)-Endoxifen；N-Desmethyl-4-hydroxy Tamoxifen
他莫昔芬代谢物；N-去甲基-4-羟基他莫昔芬 (1:1 E/Z混合物)
(E/Z)-Endoxifen；N-Desmethyl-4-hydroxy Tamoxifen
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产品编号： CDR292043
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CAS号： 110025-28-0
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分子式：C25H27NO2
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分子量：373.49
英文别名：
4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (E/Z)-Endoxifen; 4OHNDtam;
熔点：
69-74°C
可溶性：
Chloroform, Dichloromethane, DMSO, Methanol
性状：
浅棕色至浅紫色固体
储存条件：
-20°C
参考文献：
Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),
A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
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