阿托伐他汀钙杂质A
阿托伐他汀钙杂质A(USP)；去氟阿托伐他汀钙
Defluoro Atorvastatin Calcium Salt
阿托伐他汀钙杂质A(USP)；去氟阿托伐他汀钙
Defluoro Atorvastatin Calcium Salt
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产品编号： CDR289875
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CAS号： 433289-83-9
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分子式：C66H68CaN4O10
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分子量：1119.36
英文别名：
(βR,δR)-β,δ-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Calcium Salt (2:1); USP Atorvastatin Related Compound A
熔点：
>193°C (dec.)
可溶性：
DMSO, Methanol
性状：
白色固体
SMILES：
CCNCCNC(C1=C(C)NC(/C=C2\C(=O)NC3C=CC(=CC\2=3)F)=C1C)=O
储存条件：
-20°C
参考文献：
Gupta, L. et al.: Spect. Acta. Mol. Biomol. Spect., 97, 495 (2012); Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),
Desfluoro Atorvastatin is an impurity in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
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