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5'-脱氧-5'-甲硫基腺苷
维生素L2;5'-脱氧-5'-(甲硫基)腺苷
5'-Deoxy-5'-(methylthio)adenosine
  • 产品编号: CDR242600

  • CAS号: 2457-80-9

  • 分子式:C11H15N5O3S

  • 分子量:297.33

英文别名:
5'-S-Methyl-5'-thioadenosine; 5'-(Methylthio)-5'-deoxyadenosine; 5'-(Methylthio)adenosine; 5'-Deoxy(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine; 5'-S-Methylthioadenosine; NSC 335422; Vitamin L2; 1-(6-Amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-β
熔点:
205-210ºC
可溶性:
DMSO (Slightly), Methanol (Slightly)
性状:
灰白色固体
储存条件:
冷藏
参考文献:
Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),
5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
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