N-去[2-(甲磺酰基)乙基]拉帕替尼
拉帕替尼代谢物；N-去[2-(甲磺酰基)乙基]拉帕替尼
N-De[2-(methylsulfonyl)ethyl] Lapatinib
拉帕替尼代谢物；N-去[2-(甲磺酰基)乙基]拉帕替尼
N-De[2-(methylsulfonyl)ethyl] Lapatinib
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产品编号： CDR231270
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CAS号： 697299-82-4
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分子式：C26H20ClFN4O2
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分子量：474.91
英文别名：
6-[5-(Aminomethyl)-2-furanyl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-4-quinazolinamine; [6-(5-Aminomethylfuran-2-yl)quinazolin-4-yl][3-chloro- 4-(3-fluorobenzyloxy)phenyl]amine;
熔点：
>141ºC (dec.)
可溶性：
DMSO (Slightly), Methanol (Slightly, Heated)
性状：
淡黄色至浅米色固体
SMILES：
ClC1=C(Cl)C=CC(NC(NC)=O)=C1
储存条件：
-20°C
参考文献：
He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),
A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.
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