5,6-脱氢-17α-度他雄胺
5,6-脱氢-17α-度他雄胺
5,6-Dehydro-17α-dutasteride
5,6-脱氢-17α-度他雄胺
5,6-Dehydro-17α-dutasteride
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产品编号： CDR229570
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分子式：C27H28F6N2O2
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分子量：526.51
英文别名：
(4aR,4bS,6aS,7R,9aS,9bS)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10-dodecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide΄
熔点：
144-146ºC
可溶性：
Chloroform (Slightly), Methanol (Slightly)
性状：
灰白色至淡黄色固体
SMILES：
O[C@@H]1CC2=CC=C3[C@@H]4CC[C@H]([C@H](C)CCCC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1
储存条件：
冷藏
参考文献：
Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),
5,6-Dehydro-17α-dutasteride is an epimer of 5,6-Dehydro-17β-dutasteride (D229560) an impurity in the synthesis of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.
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