O-去(3-氟苄基)拉帕替尼甲苯磺酸盐
拉帕替尼代谢物；O-去(3-氟苄基)拉帕替尼甲苯磺酸盐
O-De(3-fluorobenzyl) Lapatinib Ditosylate Salt
拉帕替尼代谢物；O-去(3-氟苄基)拉帕替尼甲苯磺酸盐
O-De(3-fluorobenzyl) Lapatinib Ditosylate Salt
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产品编号： CDR228750
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分子式：C36H37ClN4O10S3
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分子量：817.35
英文别名：
2-Chloro-4-[[6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinyl]amino]phenol Ditosylate;
熔点：
>176°C (dec.)
可溶性：
DMSO, Methanol
性状：
黄色固体
SMILES：
CC1C=CC=C(C(N(C(C([2H])([2H])[2H])([2H])[2H])C(C([2H])([2H])[2H])([2H])[2H])=O)C=1
储存条件：
-20°C
参考文献：
He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),
A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.
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