达比加群酰基-β-D-葡糖苷酸三氟乙酸盐
达比加群代谢物；达比加群酰基-β-D-葡糖苷酸三氟乙酸盐
Dabigatran Acyl-β-D-Glucuronide Trifluoroacetic Acid Salt (80%)
达比加群代谢物；达比加群酰基-β-D-葡糖苷酸三氟乙酸盐
Dabigatran Acyl-β-D-Glucuronide Trifluoroacetic Acid Salt (80%)
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产品编号： CDR100085
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相关CAS号：1015167-40-4(单体)
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分子式：C33H34F3N7O11
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分子量：761.66
英文别名：
N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine β-D-Glucopyranuronosyl Ester;
熔点：
>155°C (dec.)
可溶性：
DMSO (Slightly), Methanol (Slightly, Heated)
性状：
灰白色至浅米色固体
SMILES：
O[Cr+](O)(O)Cl.Cl.O
储存条件：
-20°C
参考文献：
Becker, B., et al.: Biochem. J., 314, 249 (1996), Bailey, M., et al.: Chem. Biol. Interact., 145, 117 (2004), Blech, S., et al.: Drug Metab. Dispos., 2008, 36, 386 (2008),
The major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys. NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (β anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (α and β anomers).
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