环杷明
环杷明；环巴胺
Cyclopamine
环杷明；环巴胺
Cyclopamine
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产品编号： CCR988400
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CAS号： 4449-51-8
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分子式：C27H41NO2
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分子量：411.62
英文别名：
(2’R,3S,3’R,3’aS,6’S,6aS,6bS,7’aR,11aS,11bR)-1,2,3,3’a,4,4’,5’,6,6’,6a,6b,7,7’,7’a,8,11,11a,11b-Octadecahydro-3’,6’,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2’(3’H)-furo[3,2-b]pyridin]-3-ol; 11-Deoxojervine; (3β,23β)-17,23-Epoxyveratraman-3-ol; 11-Deoxyjervine;
熔点：
>227°C (dec.)
可溶性：
Chloroform, DMSO (1mg/200 µL, heated to 70°C), Hot Methanol
性状：
白色至灰白色固体
SMILES：
C1(C(O)=O)CCCC1C(O)=O
储存条件：
-20°C
参考文献：
Kanda, S., et al.: J. Biol. Chem., 278,10, 8244 (2003), Rao, et al.: Development, 130, 1549 (2003), Taipale, J., et al. Nature 406, 1005 (2000), Perron, M., et al. Development 130, 1565 (2003), Watkins, D.N., et al.: Nature, 422, 313 (2003)
Cyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched. Solubility: 1mg of Cyclopamine dissolves in 0.2ml DMSO with heating to approximately 70 degrees (ca. 12 mmol sol.) Solubility: 4mg of Cyclopamine dissolves in 1ml 95% Ethanol
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